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Updated: Jul 21, 2026

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[扩散性大B细胞淋巴瘤与中央庞丁菌解没有血清水平的快速变化]

Aika Kitamura¹, Makoto Osada¹, Hisako Kunieda¹

¹Department of Hematology, Saiseikai Central Hospital.

[Rinsho ketsueki] The Japanese journal of clinical hematology

|February 9, 2025

概括

在恶性淋巴瘤病例中,中央突髓溶解 (CPM) 是罕见的. 这项研究介绍了一例罕见的CPM二次扩散大B细胞淋巴瘤 (DLBCL),突出了独特的诊断挑战和治疗结果.

科学领域:

神经学神经学
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

中枢突髓溶解 (CPM) 是一种罕见的神经疾病,通常与低血症的快速纠正有关.
恶性淋巴瘤次要的CPM异常罕见,记录的病例有限.
扩散性大B细胞淋巴瘤 (DLBCL) 是一种侵略性的非霍奇金淋巴瘤.

研究的目的:

报告一种罕见的DLBCL二次性CPM病例.
讨论在缺少低血症的情况下诊断的挑战.
审查有关与恶性淋巴瘤相关的CPM的现有文献.

主要方法:

一位80岁的厌食症妇女的案例介绍,诊断为DLBCL.
大脑MRI用于识别骨病变.
对类似的淋巴瘤二次性CPM病例的文献综述.

主要成果:

患者在开始DLBCL治疗后出现神经症状 (,意识变化).
大脑MRI显示了特征性的对称庞丁病变,没有加多增强.
根据MRI发现和文献审查,尽管没有下血病史,但仍确诊了CPM.
对DLBCL的持续化疗导致了骨损伤和神经状态的改善.

结论:

在没有电解质异常的情况下,CPM也可能发生在DLBCL的次要状态下.
在这种情况下,早期识别和持续的淋巴瘤治疗对于管理CPM至关重要.
这一案例强调了在淋巴瘤患者中考虑CPM的重要性,这些患者有神经缺陷.

关键词:

案例报告案例报告中央庞丁骨髓溶解 (central pontine myelinolysis) 是一种神经分裂的过程.扩散大的B细胞淋巴瘤.

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