相关实验视频

Updated: May 28, 2025

Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay
11:22

Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay

Published on: August 26, 2018

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转录组范围的替代拼接和转录级差异表达分析死后的莱维体痴呆症大脑

Thomas R Goddard1, Keeley J Brookes2, Kevin Morgan3

  • 1Institute of Mental Health, Mental Health and Clinical Neurosciences Academic Unit, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.

Acta neuropsychiatrica
|February 9, 2025
PubMed
概括

勒维体痴呆症 (LBD) 显示出广泛的RNA拼接变化. 转录层次分析揭示了对于LBD病理学和潜在生物标志物至关重要的特定差异表达的转录.

关键词:
这就是GABRB3B3的原因.莱维体痴呆症 (Lewy体痴呆症) 是一种疾病.通过RNA测序进行RNA测序.在TEMEM18中,我们可以使用TEMEM.替代性拼接是一种替代性的拼接.

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相关概念视频

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
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