儿科患者的维生素D状况和影响因素的评估
Serap Bilge1, Sema Nur Taşkın2
1Department of Pediatric Neurology, Ministry of Health, Children Hospital of Diyarbakır, Diyarbakır, Turkey. sarabsmustafa@hotmail.com.
Italian journal of pediatrics
|February 9, 2025
概括
抗发作药物可以导致的儿童缺乏维生素D. 诸如抗发作药物的数量和类型,的持续时间和MRI发现等因素会影响维生素D水平.
科学领域:
- 儿科神经学 儿科神经学
- 内分泌学 在内分泌学.
- 临床药理学 临床药理学
背景情况:
- 抗发作药物 (ASM) 与患者的维生素D状况异常有关.
- 低维他命症D在接受ASM治疗的儿童中是一个重大问题.
研究的目的:
- 在接受ASM的儿科患者中鉴定维生素D缺乏症 (维生素D不足) 的危险因素.
- 分析ASM使用与儿童维生素D水平之间的关系.
主要方法:
- 一项横截面的回顾性队列研究,涉及127名小儿患者,从2021年12月至2022年12月接受ASM治疗.
- 对人口统计数据,发作类型,饮食,体育活动,持续时间和使用的ASM类型的分析.
- 测量血清中的25...OH) D水平.
主要成果:
- 在研究的儿科患者中,近一半 (47%) 患有维生素D缺乏 (血清25(OH) D<20 ng/mL).
- 与非酶诱导ASMs (27.6 ± 12.2 ng/mL) 相比,在用酶诱导ASMs (21.76 ± 19.7 ng/mL) 和联合ASMs (13.96 ± 7.9 ng/mL) 治疗的患者中,维生素D水平显著降低 (p < 0.001).
- 在冬季/秋季期间,血清中平均25(OH) D水平为24.2 ± 14.2 ng/mL.
结论:
- ASM的数量,酶诱导ASM的使用,的持续时间和MRI发现是影响儿科患者维生素D状况的关键因素.
- 这些发现凸显了在ASM上监测患者儿童的维生素D水平的必要性.
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