调查收入对健康的因果关系,使用双样本的门德尔随机化
Erik Igelström1, Marcus R Munafò2,3, Ben M Brumpton3,4
1MRC/CSO Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, Glasgow, UK. Erik.Igelstrom@glasgow.ac.uk.
BMC global and public health
|February 9, 2025
概括
更高的收入因果关系降低了抑郁症,死亡风险和吸烟. 然而,关于酒精对酒精,福祉和其他健康结果的影响的证据有限,关于混因素的警告是有限的.
科学领域:
- 遗传学和健康经济学 遗传学和健康经济学
- 流行病学和公共卫生.
背景情况:
- 收入与许多健康结果有关,但因果关系尚不清楚.
- 观察性研究面临着混的问题,需要使用替代的调查方法.
研究的目的:
- 调查职业收入对心理健康,身体健康和与健康有关的行为产生的因果关系.
- 用孟德尔随机化 (MR) 和其他先进的统计技术来解决混和类型.
主要方法:
- 采用两个样本的门德尔随机化 (MR),使用来自非相关个体的遗传数据.
- 使用MR-Egger,加权中位数和MR-PRESSO进行评估性.
- 使用 CAUSE,多变量 MR (包括教育),家庭内部分析和双向 MR 进行稳定性.
主要成果:
- 10%的收入增加与抑郁症 (OR 0.92),死亡 (OR 0.91) 和持续吸烟 (OR 0.91) 的几率降低,以及较低的BMI (-0.06 SD).
- 很少有证据表明收入对酒精消费或主观幸福感的影响.
- 在收入和教育方面的遗传变异之间观察到显著的重叠 (29/36变异).
结论:
- 对于因果收入对特定心理健康和行为结果的影响,MR提供了有限的支持.
- 洞穴存在的原因是家庭层面的因素和教育的类效应的混.
- 需要对更大规模的基于家庭的队列进行进一步的研究,以澄清收入与健康的复杂关系.
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