三甘油糖指数作为H型高血压患者心力衰竭风险的生物标志物
Zhengwen Xu1, Xisheng Yan1, Dongsheng Li2
1Department of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, 430074, Hubei, China.
Scientific reports
|February 9, 2025
概括
三甘油-葡萄糖 (TyG) 指数是胰岛素抵抗的标志物,可显著预测H型高血压患者心力衰竭 (HF) 风险. 较高的TyG指数值表明患HF的可能性更高,特别是在糖尿病患者中.
科学领域:
- 心血管医学 心血管医学
- 代谢综合征是代谢综合征的一种.
- 高血压研究 高血压研究
背景情况:
- 心力衰竭 (HF) 是一个主要的全球健康问题,特别流行于H型高血压的个体,其特点是高血压和高同氨酸水平.
- 三甲糖-葡萄糖 (TyG) 指数,一种已验证的胰岛素抵抗代用标记,已成为心血管事件的潜在预测因子,但其在H型高血压患者群体内HF发展中的特定作用需要进一步调查.
研究的目的:
- 在被诊断为H型高血压的患者中,调查甘油三指数 (TyG) 和心力衰竭 (HF) 发生率之间的关联.
- 评估TyG指数在这个特定患者队列中对HF风险分层的预测性能.
主要方法:
- 进行了一项回顾性队列研究,涉及1200名H型高血压患者.
- 三甲糖-葡萄糖 (TyG) 指数是使用禁食三甲糖和葡萄糖水平计算的.
- 调整了关键的人口统计和生活方式因素的多变量考克斯回归分析,用于评估TyG指数对HF发病率的影响.
主要成果:
- 总共有254名患者 (21.2%) 在24个月的中位随访期间患上心力衰竭.
- 升高的甘油三指数 (TyG) 值与心力衰竭风险增加显著相关 (HR 1.45 每单位增加,p < 0.001).
- 较高的TyG指数和HF风险之间的关联在糖尿病患者中更为明显. TyG指数表现出良好的预测准确性 (AUC = 0.78),截止值为8.88.
结论:
- 三甲糖-葡萄糖 (TyG) 指数是H型高血压患者心力衰竭发病率的重要独立预测指标.
- 泰格指数为高风险人群,特别是糖尿病人群中心力衰竭风险早期分层提供了一种具有成本效益的工具.
- 将TyG指数评估例行整合到临床实践中可能会增强H型高血压患者的管理并改善患者的治疗结果.
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