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Updated: May 5, 2026

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
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In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

Published on: February 27, 2019

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反对PD-L1表达细胞的RevCAR介导的T细胞反应将抑制转化为激活

Eugenia Crespo1, Liliana R Loureiro1, Antonia Stammberger2

  • 1Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.

NPJ precision oncology
|February 9, 2025
PubMed
概括

这项研究引入了一种用于CAR T细胞治疗的新型PD-L1向系统,通过克服免疫抑制性瘤微环境 (TME) 来提高其对固体瘤的有效性. RevCAR系统在重定向T细胞以消除PD-L1表达癌细胞方面表现有前途.

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