下垂体腺瘤的头痛:治疗后的频率,特征和结果
Cristiane R Scaf1, Ananda Altoé2, Nina Ventura2,3,4
1Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital Universitário, Clementino Fraga Filho - Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Pituitary
|February 9, 2025
概括
脑垂体腺瘤 (PA) 患者的头痛很常见,偏头痛和张力类型是最常见的. 治疗可以在50%的病例中缓解头痛,特别是在非功能性垂体腺瘤 (NFPA) 中.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 脑垂体腺瘤 (PA) 患者的头痛是常见的症状,但它的表现,病理生理学和治疗结果仍在争论中.
- 了解PA中头痛特征对于改善患者管理和生活质量至关重要.
研究的目的:
- 为了确定脑垂体腺瘤患者头痛的患病率和表型.
- 为了确定与头痛相关的因素,并评估PA治疗对头痛解决问题的影响.
主要方法:
- 一组以前没有接受过治疗的成年垂体腺瘤患者使用基于国际头痛疾病分类第三版的问卷进行了评估.
- 患者在手术或医疗干预后接受了前性随访 (治疗后3-6个月).
主要成果:
- 在104名PA患者中,头痛影响了62%的患者,主要呈现为偏头痛或紧张型头痛.
- 头痛的患病率在前性腺瘤 (83%) 和壮症患者中较高,其生长激素 (GH) 水平较高.
- 在50%的患者中,治疗导致头痛完全消失,非功能性垂体腺瘤 (NFPA) 的发病率 (83%) 与前性腺瘤 (33%) 相比较高.
结论:
- 偏头痛和紧张型头痛是脑垂体腺瘤患者中最常见的表型.
- 三原体自主脑膜炎 (TACs) 仅在益生菌瘤患者中观察到.
- 在相当一部分患者中,PA治疗显著改善或消除了头痛,不同瘤类型的疗效不同.
相关概念视频
The Pituitary Gland
6.3K
The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
6.3K
Hormones of the Pituitary Gland
6.2K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
6.2K
Open Angle Glaucoma: Treatment
386
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
386
Major Hormones and Their Functions
307
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
307
Adrenal Gland Disorders
1.3K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.3K
Chronic Pancreatitis I: Introduction
64
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
64


