由METTL3介导的N6-Methyladenosine修饰促进DNA-PKcs表达,以诱导骨髓瘤中的anlotinib耐药性

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Yining Zhang1,2, Guohong Shen3, Dan Zhang4

  • 1The First Clinical College of Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Clinical and translational medicine
|February 9, 2025
PubMed
概括

通过调节自,DNA-PKcs促进骨髓瘤中的anlotinib耐药性. METTL3通过诱导PRKDCmRNA的m6A修饰来增强这种抗性,从而增加DNA-PKcs表达. 针对METTL3/PRKDC可能会改善骨髓瘤治疗.

关键词:
这就是DNA-PKcscs.在METTL3中,METTL3是METTL3的第一个类型.安洛丁尼布的使用方法m6A 一个很好的.骨质肉瘤是骨质肉瘤的一种疾病.

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