预测感染性内心炎患者中风:风险因素的系统审查和元分析
Ammar Jumah1,2, Ahmed Mohamedelkhair2, Abdelrahman Elfaham2
1Department of Vascular Neurology, Emory University, Atlanta, GA, USA.
概括
在传染性内心炎 (IE) 中预测中风具有挑战性. 这次审查确定了中风的关键风险因素,包括黄金葡萄球菌感染和植被大小,有助于临床预测.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 神经系统并发症,包括缺血性和出血性中风,是已知的感染性内心炎 (IE) 的风险.
- 预测IE患者中风风险仍然不确定.
- 本研究解决了IE中更好的风险分层的需求.
研究的目的:
- 系统地审查和对IE入院患者中风风险相关的因素进行元分析.
- 确定IE中急性缺血性中风 (AIS) 和内出血 (ICH) 的预测因素.
主要方法:
- 在Ovid MEDLINE,EMBASE和Web of Science数据库中进行系统搜索.
- 包括评估IE患者AIS或ICH风险的文章.
- 使用Cochrane工具对赔率比率和偏差风险评估的元分析.
主要成果:
- 金色葡萄球菌感染 (OR 3.05) 和植被大小增加 (OR 1.26) 显著增加了AIS的风险.
- 额外的AIS危险因素包括高强度的经多普勒信号,高血压,心房动和高脂血症.
- 血小板缺血,真菌动脉瘤,以前的中风史和脑微型出血增加了ICH风险.
结论:
- 鉴定的因素可以帮助医生预测IE患者中风风险.
- 心声和神经成像的发现是有信息的.
- 同病症和实验室值也有助于预测IE相关的中风.
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