在大鼠中,基底前脑向后皮和皮皮层的投射
Hideki Kondo1, Laszlo Zaborszky1
1Center for Molecular and Behavioral Neuroscience, Rutgers, the State University of New Jersey, Newark, New Jersey, USA.
The Journal of comparative neurology
|February 10, 2025
概括
基础前脑通过胆固醇和非胆固醇通路向前带状皮层 (ACC) 和后皮层 (RSC) 发射. 这些预测根据大脑区域和细胞类型而异,揭示了复杂的连接模式.
科学领域:
- 神经科学是一个神经科学.
- 神经解剖学是一个神经解剖学.
- 细胞神经科学 细胞神经科学
背景情况:
- 基础前脑 (BF) 通过广泛的投射调节皮质激活.
- 之前的研究表明,BF对皮质区域的预测是特定的.
- 了解这些投影是解读皮质功能的关键.
研究的目的:
- 为了研究从BF到老鼠后皮质 (RSC) 和前带皮质 (ACC) 的胆固醇和非胆固醇投射.
- 将特定的BF次区域映射到RSC和ACC.
- 根据神经递质类型和皮质位置来区分投影模式.
主要方法:
- 在老鼠模型中使用了逆行追踪剂 (快蓝和金).
- 结合的标记剂注射与胆乙转移酶 (ChAT) 免疫染色.
- 分析了BF子区域的投影神经元起源,如中枢球 (GP),对角带的垂直肢体 (VDB),中枢隔膜 (MS) 和对角带的水平肢体 (HDB).
主要成果:
- 无论是RSC还是ACC,都会收到胆固醇和非胆固醇预测,主要来自HDB和VDB.
- 脑前皮层 (ACC) 和前皮层 (PL) 接收来自面向GP的投影,而RSC则从VDB和MS获得更强的非胆性输入.
- 在GP和MS/VDB非胆性投射中发生逆转,沿着从PL到RSC的 rostrocaudal轴发生逆转.
- 胆固醇神经元约占ACC的37%,RSC投射神经元的33%.
- 在MS/VDB和HDB中的一个小数量的投影神经元对RSC和ACC都具有投影性.
结论:
- ACC和RSC从BF收到重叠和不同的预测.
- 胆固醇和非胆固醇预测在不同的BF亚区和皮质标之间有很大的差异.
- 这些发现突显了BF皮质电路的复杂和差异化组织.
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