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斯特里宾托的代谢激活与细胞毒性相关

Ziying Jiang1, Yang Wang2, Guode Zhao1

  • 1Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Chemical research in toxicology
|February 10, 2025
PubMed
概括

类药物斯蒂里宾托尔 (SRP) 可能形成有毒代谢物. 这种反应性代谢物,一种α,β不和,与SRP有关.

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Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
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