皮肤上PD-1抑制剂的副作用:一个单中心的回顾性研究
Melánia Pozsgai1, Udoh Frieda-Rex Sebastian2, Péter Oláh1
1Department of Dermatology, Venerology and Oncodermatology Clinical Center, University of Pécs, Pécs, Hungary.
International journal of dermatology
|February 10, 2025
概括
免疫检查点抑制剂 (ICI) 有效治疗黑色素瘤,但可能导致皮肤问题. 在接受PD-1抑制剂治疗的黑色素瘤患者中,这些皮肤不良事件 (cAEs) 可能表明预后更好.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫检查点抑制剂 (ICI),特别是PD-1抑制剂,已经彻底改变了癌症治疗,特别是黑色素瘤.
- 然而,与免疫相关的不良事件 (irAEs),主要是皮肤毒性,是与ICI使用相关的重大临床挑战.
研究的目的:
- 研究在接受PD-1抑制剂治疗的黑色素瘤患者皮肤副作用的谱和临床意义.
- 评估皮肤学不良事件与患者结果之间的关联,包括无进展生存期 (PFS) 和整体生存期 (OS).
主要方法:
- 一项回顾性,单中心研究分析了174名患有III或IV阶段黑色素瘤的患者,他们在2015年8月至2022年5月期间接受PD-1抑制剂单疗法 (pembrolizumab或nivolumab).
- 收集和分析了皮肤不良事件 (cAEs) 和其管理的数据.
主要成果:
- 29%的患者经历了cAEs,白风,黄斑皮疹和是最常见的.
- 对cAEs的治疗主要涉及局部皮质类固醇和软化剂.
- cAEs的发生与改善的PFS (p=0.007) 和OS (p=0.026) 显著相关,这表明预后价值.
结论:
- 接受PD-1抑制剂的黑色素瘤患者的皮肤不良事件具有显著的预后价值.
- 皮肤科医生在管理这些毒性和优化瘤治疗策略方面在多学科癌症护理框架内发挥着至关重要的作用.
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