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通过各种途径通过谷氨调节术后认知功能障碍:叙述性审查

Yan Lin He¹, Ying Zhang^2,3, Qing Liu^1,2

¹Department of Anesthesiology, He jiang Hospital of Traditional Chinese Medicine, Southwest Medical University, Luzhou, China.

Journal of biochemical and molecular toxicology

|February 10, 2025

概括

谷氨 (GSH) 可能治疗术后认知功能障碍 (POCD),这是与神经炎症和氧化应激有关的常见并发症. 需要进一步的研究来了解GSH.

科学领域:

神经科学是一个神经科学.
生物化学生物化学

背景情况:

手术后认知功能障碍 (POCD) 是手术和麻醉后的一种普遍的神经并发症,患病率随着年龄的增长而增加.
POCD对患者,家庭和社会产生负面影响,神经炎症和氧化应激是主要被认可的机制.
谷氨酸 (GSH) 是一种强大的减少剂,与POCD的病理生理学有关.

研究的目的:

探索谷氨 (GSH) 在缓解术后认知功能障碍 (POCD) 中的潜在作用.
审查关于POCD机制的当前文献,包括神经炎症和氧化应激,以及它们与GSH的关系.

主要方法:

通过PubMed和Web of Science等医疗数据库进行了全面的文献搜索.
关键词包括POCD,GSH,神经炎症,氧化应激,微质细胞,星球细胞,寡质细胞,铁和BDNF.
原创的文章,评论和医学书籍都被纳入了分析.

主要成果:

经过审查的文献表明,Glutathione (GSH) 具有作为POCD治疗剂的潜力.
作为一种强大的减少剂,GSH的作用可以抵消POCD所涉及的氧化应激.

结论:

针对POCD的向治疗仍然有限,这强调了预防策略的重要性.
对GSH和POCD之间的关系进行进一步的研究是有必要的,以便全面了解和开发有效的治疗方法.

关键词:

谷氨 (GSH) 的使用.神经炎症是一种神经炎症.氧化应激是一种氧化应激.手术后的认知功能障碍 (POCD)

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