1型糖尿病患者的短期糖尿病视网膜病变状态,开始自动化胰岛素输送
Matilda M E Johansson1,2, Francesc March de Ribot3, Mary-Jane Sime3
1Department of Women's and Children's Health, University of Otago, Dunedin, New Zealand.
Diabetes technology & therapeutics
|February 10, 2025
概括
大多数开始自动胰岛素输送 (AID) 的人保持或改善了糖尿病视网膜病变 (DR) 等级. 在AID开始时的年龄较小似乎可以防止DR恶化,这突显了AID在1型糖尿病管理中的安全性.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 快速改善血糖控制可以加速糖尿病视网膜病变 (EWDR) 的早期恶化.
- 自动化胰岛素输送 (AID) 系统提供快速的血糖改善,需要对糖尿病视网膜病变 (DR) 结果进行安全评估.
- 有限的数据存在于AID启动后的短期DR结果.
研究的目的:
- 在启动自动胰岛素输送 (AID) 后,研究1型糖尿病患者的短期糖尿病视网膜病变 (DR) 结果.
- 评估AID系统在使用最初几个月的DR进展方面的安全性.
主要方法:
- 这是一项回顾性观察性研究,涉及来自新西兰和澳大利亚四个中心的165名1型糖尿病患者 (年龄≥13岁).
- 在AID启动 (≥6个月使用) 之前和之后收集人口统计,临床特征和DR分级数据.
- 统计分析以评估DR等级的变化,并确定恶化的风险因素.
主要成果:
- 大多数参与者 (60%) 保持稳定的DR等级,而19%的DR等级有所改善,21%的DR等级有所恶化.
- 观察到平均HbA1c改善为1.0±1.3个百分点.
- 在≥18岁时开始AID是DR恶化的重要风险因素 (P=0.028).
- 增殖性变化或需要光凝的发生在3%的参与者中,主要是那些有先前存在的DR,糖尿病持续时间长或其他并发症的人.
结论:
- 大多数启动AID的个人经历了稳定或改善的糖尿病视网膜病变等级.
- 对于大多数1型糖尿病患者来说,在短期内,AID的启动似乎是安全的,这与DR的结果有关.
- 在AID开始时的年龄<18岁可能有助于防止DR恶化.
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