小分子和CXCR4对抗剂. 从2019年到2024年进行专利审查
Zafer Sahin1, Yesim A Tahirovic1, Jiafeng Geng1
1Department of Chemistry, Emory University, Atlanta, GA, USA.
Expert opinion on therapeutic patents
|February 10, 2025
概括
最近的FDA批准标志着CXCR4对抗剂的重大进展. 专利分析揭示了小分子和的渐进进步,为下一代疗法铺平了道路.
科学领域:
- 免疫学和药理学 免疫学和药理学
- 药物的发现和开发.
背景情况:
- 化基因受体CXCR4对于免疫调节和疾病病理学至关重要.
- 虽然第一个CXCR4抗剂 (plerixafor) 在2007年获得批准,但近年来已经出现了抗剂 (motixafortide, 2023) 和口服小分子 (mavorixafor, 2024) 抗剂.
研究的目的:
- 对2019-2024年关于CXCR4抗剂的专利文献进行审查.
- 确定小分子和抑制剂开发和治疗应用的趋势.
主要方法:
- 搜索了SciFinder (CAS) 和谷歌专利,使用术语"CXCR4对手".
- 将相关专利分为小分子和类别.
- 专注于2019年至2024年间发表的专利.
主要成果:
- 专利景观显示了有限的新型化学类型,大多数小分子是现有类别的扩展.
- 基于的治疗方法的知识产权不如小分子的知识产权那么重要.
- 最近的专利已经确定了CXCR4抗剂的多种新疗法用途.
结论:
- 最近的FDA批准证实了CXCR4抗剂的重大进展.
- 未来的研究很可能会专注于开发具有改进性质和新型应用的第二代和第三代化合物,并可能从审查的知识产权中汲取.
关键词:
这是一种CXCR4抗剂.癌症 癌症 癌症 癌症艾滋病病毒 艾滋病病毒 艾滋病病毒这里是WHIM.化学物质化学物质是化学物质.造血干细胞 造血干细胞这是一种炎症炎症炎症炎症.中性变质症 中性变质症 中性变质症更多相关视频
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