在口服安非他胺后致命的中毒:两个病例报告
Evelyn Pawlik1, Felix Mayer2, Oliver Temme1
1Forensic Toxicology, Institute of Legal Medicine Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, NRW, Germany.
Forensic science international. Synergy
|February 10, 2025
概括
两名男子死于高剂量的口服液体安非他胺. 法医分析在所有生物样本中检测到胺,其中尿液和胃中度最高. 发现的胺副产品不一致.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胺是一种被广泛滥用的兴奋剂,具有已知的不良影响,包括高温症和食欲抑制.
- 勒卡特合成是生产安非他胺的常见途径,通常产生副产品,如4-甲基-5-烯胺 (4-M-5-PP),N,N-di(β-烯) 胺 (DPIA) 和N-formylamphetamine (NFA).
- 胺副产品对人类的毒性尚未得到充分证实.
研究的目的:
- 报告和分析两起口服安非他胺制剂摄入导致死亡的病例.
- 在各种生物矩阵中量化安非他胺及其副产品.
- 为了比较毒理学发现,并讨论胺在体内的分布.
主要方法:
- 死后检查两个已故人的生物液体和组织.
- 使用高性能液体染色学与二极管阵列检测 (HPLC/DAD),液体染色学-质谱学 (LC/MS),气体染色学-质谱学 (GC/MS) 和气体染色学与火焰电离检测 (GC/FID) 的分析.
- 采用了包括流体-流体提取在内的提取技术.
主要成果:
- 在所有检查的生物样本 (心脏血液,大腿静脉血液,尿液,脑脊液,玻璃体皮质,胃内容,心肌,肺,肝脏,胆囊,大脑,脏,骨肌肉) 中检测到安非他胺.
- 在尿液 (2600微克/毫升,案例1) 和胃内含量 (14,000微克/毫克,案例2) 中观察到的安非他胺度最高.
- 在一个案例中,在心脏血液中发现了胺副产品DPIA;没有检测到NFA和4-M-5-PP.
结论:
- 高口服液体安非他胺制剂的摄入量可能是致命的.
- 在这两种情况下,安非他胺在整个身体中广泛分布.
- 需要进一步的研究来阐明安非他胺副产品的毒性.
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