通过尿道的水蒸气废除:一个新的前列腺癌管理策略的潜力
Christopher A Warlick1, Benjamin D Spilseth2, Christopher M Dixon3
1Department of Urology, University of Minnesota, Minneapolis, MN, USA.
Research and reports in urology
|February 10, 2025
概括
通过尿道的水蒸气除为局部前列腺癌提供了一种安全有效的新疗法. 这种微创手术在中等风险患者中显示出高负面活检率和低不良事件.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 最少侵入性的手术
背景情况:
- 前列腺癌的治疗需要针对局部疾病的精确方法.
- 热能为组织切除提供了一种有针对性的方法.
- 水蒸气切除是一种新的治疗方式.
研究的目的:
- 评估通过尿道半球水蒸气切除的安全性和瘤结果.
- 评估这种新方法在患有中等风险局部前列腺癌的男性中的有效性.
- 为了确定再治疗残留或新疾病的可行性.
主要方法:
- 一项前性单臂研究,涉及患有单边,中等风险局部性前列腺癌的男性 (格里森等级组2).
- 通过囊镜和直肠横外超声波 (TRUS) 引导的水蒸气 (~103°C) 的输入.
- 六个月的随访多参数MRI (mpMRI) 融合活检;为残留/新疾病提供再治疗,随访时间延长.
主要成果:
- 15名受试者完成了治疗;14/15 (93.3%) 在治疗后12-18个月或再治疗后获得了负面活检 (≥GG2).
- 四个受试者在6个月后需要进一步的治疗 (两个残留,两个逆侧疾病).
- 副作用是轻度/中度和短暂的,没有报告严重事件.
结论:
- 通过尿道管的水蒸气除显示出较低的发病率和可接受的瘤结果.
- 该程序有效治疗局部前列腺癌,包括对残留病变或新病变进行重新治疗.
- 水蒸气切除为局部性前列腺癌提供了一个有希望的新管理策略.
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