唐氏综合征和临界病儿科患者的结局
José Tantaleán Da Fieno1, Rosa León Paredes2, Patricia Palomo Luck3
1Faculty of Human Medicine, Universidad Nacional Federico Villarreal, Lima, Peru.
Frontiers in pediatrics
|February 10, 2025
概括
入住儿科重症监护室 (PICU) 的唐氏综合征 (DS) 儿童面临更高的医疗相关感染 (HAI) 和长时间机械通风的风险. 重症儿童的体重不足状况也增加了通风使用和持续时间的可能性.
科学领域:
- 儿科重症监护室的儿童重症监护室
- 临床结果研究研究
- 唐氏综合征研究 唐氏综合征研究
背景情况:
- 关于儿童重症监护室 (PICU) 中患有唐氏综合征 (DS) 的儿童的数据有限且相互矛盾.
- 了解这种脆弱人群的临床结果和营养状况对于改善护理至关重要.
研究的目的:
- 为了调查唐氏综合症 (DS) 与儿童患者的临床结果之间的关联,这些患者被录入PICU.
- 评估严重疾病儿童的营养状况.
主要方法:
- 来自秘鲁利马一家三级护理儿童医院的数据库的二次分析.
- 包括525名儿科患者,收集人口统计,临床和营养数据.
- 应用Cox和Poisson回归分析来确定DS与死亡率,停留时间,机械通风持续时间和医疗相关感染 (HAI) 等结果之间的关系.
主要成果:
- 患有DS的儿童年轻,患有更多的并发症,先天性心脏病和体重不足.
- 糖尿病与更高的死亡率,增加的HAI,更长时间的机械呼吸 (DMV),更长时间的PICU停留,以及更少的无呼吸器日 (VFD) 相关.
- 经过调整后的分析显示,患有DS的儿童有明显更高的HAI风险 (RR 2.95) 和更长的DMV (RR 1.43). 体重不足与使用更多的MV和使用更长的DMV有关.
结论:
- 患有唐氏综合征 (DS) 的重症儿童患有医疗相关感染 (HAI) 和长期机械通风 (MV) 的风险增加.
- 重症儿童的体重不足状况独立地与使用MV的更高可能性和通风持续时间的延长有关.
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