研究皮肤高级糖化终端产品与糖尿病心血管自主神经病变的相关性
Yucheng Fang1, Wu Dai1, Yonghong Cao1
1Department of Endocrinology, Hefei second People's Hospital, Hefei, 230011, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|February 10, 2025
概括
先进的糖化终产品 (AGEs) 和高禁食血葡萄糖 (FPG) 与糖尿病心血管自主神经病变 (DCAN) 有关. 皮肤AGE积累与DCAN患者的年龄,性别和血管斑块等因素相关.
科学领域:
- 内分泌学和新陈代谢学
- 心血管研究研究心血管研究
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病心血管自主神经病变 (DCAN) 是2型糖尿病 (T2DM) 的严重并发症.
- 先进的糖化终产物 (AGEs) 与糖尿病并发症有关,但它们在DCAN中的特定作用需要进一步阐明.
- 了解与DCAN和AGE积累相关的因素对于患者管理至关重要.
研究的目的:
- 研究2型糖尿病 (T2DM) 患者的高级糖化终产品 (AGEs) 和糖尿病心血管自主神经病变 (DCAN) 的皮肤积累之间的相关性.
- 确定影响DCAN发生率的临床因素.
- 在被诊断为DCAN的患者中分析与皮肤AGE积累相关的因素.
主要方法:
- 192名T2DM患者的队列根据尤文测试结果被分为DCAN (n=121) 和No_DCAN (n=71) 组.
- 对所有参与者的皮肤AGE积累量度.
- 使用多变量逻辑回归,斯皮尔曼和皮尔森相关性分析来评估影响因素和相关性.
主要成果:
- 与没有DCAN组相比,DCAN组的糖尿病视网膜病变 (DR),禁食血葡萄糖 (FPG) 和皮肤AGE的比率显著更高 (P<0.05).
- FPG,联合DR和皮肤AGE被确定为影响DCAN的重要独立因素 (P<0.05).
- 在DCAN患者的皮肤AGE积累与性别,血管斑块的存在,年龄,糖尿病持续时间,透气血压,尿酸,肌素和UACR水平相关 (P<0.05).
结论:
- 皮肤AGE,联合DR和FPG是影响T2DM患者DCAN发生率的重要因素.
- 皮肤AGE积累与DCAN的发展密切相关.
- 一些临床参数,包括年龄,性别,血管状况和代谢标记,与DCAN患者皮肤AGE积累相关.
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