睡眠障碍和多发性硬化症视神经炎风险:一个回顾性队列研究
Majd A AbuAlrob1, Abdallah Hussein2, Ahmad Hassan3
1Neurology, Hamad General Hospital, Doha, QAT.
Cureus
|February 10, 2025
概括
患有多发性硬化症 (MS) 和睡眠障碍的患者面临患视神经炎的风险更高. 解决睡眠问题可能会降低这种风险,改善MS患者的治疗结果.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 眼科医生 眼科 眼科
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 光神经炎是MS的常见并发症,导致视力丧失.
- 睡眠障碍在多发性硬化症患者中很普遍,但它们对视神经炎风险的影响尚未完全理解.
研究的目的:
- 调查睡眠障碍与多发性硬化症患者视神经炎发病率之间的关联.
- 量化MS患者的视神经炎风险,包括睡眠障碍和没有睡眠障碍.
主要方法:
- 使用 TriNetX 全球协作网络进行的回顾性队列研究.
- 分析了两个匹配的队列:MS患者有睡眠障碍 (n=48,995) 和没有睡眠障碍 (n=48,995).
- 使用倾向分数匹配来控制混变量.
主要成果:
- 患有睡眠障碍的多发性硬化患者的视神经炎发病率显著增加 (3.0%的绝对风险增加).
- 这种关联产生了1.532的赔率比,表明53.2%的风险增加.
- 卡普兰-梅尔分析显示,睡眠障碍患者的视神经炎风险随着时间的推移增加了31.5%.
结论:
- 睡眠障碍与多发性硬化症患者视神经炎风险增加有显著的相关性.
- 将睡眠健康评估纳入MS管理可能有助于减轻视神经炎风险.
- 对特定睡眠障碍亚型和潜在机制的进一步研究是有必要的.
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