口水的使用是否会影响口腔癌的风险? 一个全面的系统审查和元分析
Ashwini M Madawana1, Mohamad Arif Awang Nawi1, Liszen Tang1
1School of Dental Sciences, Hospital Pakar Universiti Sains Malaysia, Kota Bharu, MYS.
Cureus
|February 10, 2025
概括
长期,频繁的口水使用可能与口腔癌风险增加有关. 需要更多关于口水成分和使用模式的研究来证实这一关联.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 酒精和烟草的使用已成为口腔癌的风险因素.
- 口水使用与口腔癌 (OC) 之间的关联仍在争论中.
- 了解口水带来的潜在OC风险对于公共卫生指导至关重要.
研究的目的:
- 调查口水使用与患口腔癌的风险之间的关系.
- 综合现有关于口水使用和口腔癌发病率的证据.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在PubMed/MEDLINE,Scopus和Web of Science中搜索了观察研究.
- 包括15个病例控制研究 (6,515个病例,17,037个控制) 使用纽卡斯尔-太华尺度进行质量评估.
主要成果:
- 在每天使用口水三次或更多次 (OR=1.00) 时,没有发现口腔癌风险显著增加.
- 对40年以上使用口水的用户 (OR=1.30) 观察到潜在的风险增加,尽管基于有限的研究.
- 关于口水频率,持续时间和特定成分对口水的影响的数据有限.
结论:
- 目前的证据并没有强烈地将频繁的口水使用与口腔癌联系起来.
- 长期使用口水 (超过40年) 需要进一步调查,因为可能存在关联.
- 未来的研究应该专注于剂量反应效应,包括频率,持续时间和特定的口水配方.
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