探讨抗素在减轻微/纳米塑料诱导的生殖毒性方面的潜在保护作用:一种类固醇受体视角
Jiaojiao Zhang1, Wenyi Liu2, Fuqiang Cui2
1College of Food and Health, Zhejiang A&F University, Hangzhou, 311300, China.
Journal of pharmaceutical analysis
|February 10, 2025
概括
微塑料和纳米塑料 (MP/NP) 是破坏内分泌的化学物质,会损害生殖健康. 氨酸,像氨-3-葡萄酸,显示出通过抗氧化和抗炎作用减轻这种毒性的潜力.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 微塑料和纳米塑料 (MP / NP) 是广泛存在的污染物,作为内分泌破坏性化学物质 (EDC).
- MP/NP对人类生殖健康构成重大风险,影响男性和女性系统,生殖细胞和胚胎发育.
- 这些污染物通过氧化应激和炎症等机制诱导生殖毒性,影响性激素基因表达.
研究的目的:
- 审查天然化合物,特别是氨酸在减轻MP/NP引起的生殖毒性方面的潜力.
- 探索安托素对EDC诱导的生殖损害的保护机制.
- 突出阿西安素在调节性激素水平和减轻生殖损伤中的作用.
主要方法:
- 文献综述专注于研究MP/NP,EDC和天然化合物,如安东素.
- 分析有关安东素的生物活动的研究,包括抗氧化,抗炎和激素调节性质.
- 检查有关素-3-葡萄糖化物 (C3G) 和其对生殖器官和类固醇受体的影响的证据.
主要成果:
- 安托氨酸具有抗氧化和抗炎性质,有利于抵消MP/NP毒性.
- 丁-3-葡萄糖化物 (C3G) 对男性和女性生殖系统具有保护作用.
- 通过与雄激素和雌激素受体 (ERs) 相互作用,C3G可能会减轻生殖毒性.
结论:
- 天然化合物,特别是氨酸,为减少MP/NP对生殖健康的不利影响提供了一个有希望的策略.
- 需要进一步研究安托西亚宁机制,才能充分理解它们对环境污染物的保护作用.
- 利用植物衍生化合物可以帮助减轻内分泌干扰剂对人类生殖健康的影响.
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