门静脉血栓塞在接受塞马格卢提德治疗的患者中
Mohammed F Farooqi1, Maria Khan1, Arshad M Muhammad1
1Internal Medicine, Tawam Hospital, Al Ain, UAE.
Qatar medical journal
|February 10, 2025
概括
类似葡萄糖类-1受体激动剂 (GLP1-RAs) 像塞马格卢提德一样会导致门静脉血栓形成,这是一个罕见但严重的副作用. 医生在开处方这些流行的肥胖和2型糖尿病药物之前,应该考虑这一风险.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 血液学 血液学 血液学
背景情况:
- 肥胖和2型糖尿病 (T2DM) 是全球性的健康问题.
- 类似葡萄糖-1受体激动剂 (GLP1-RAs) 越来越多地用于T2DM和肥胖管理.
- GLP1-RAs可能与静脉血栓栓塞的风险增加有关.
研究的目的:
- 报告患者肝脏内门静脉血栓塞的病例,患者接受了semaglutide治疗.
- 为了突出与GLP1-RA使用相关的血栓形成的潜在风险.
主要方法:
- 一个59岁的T2DM妇女的病例报告,接受了semaglutide治疗.
- 进行了临床检查,实验室检查和腹部计算机断层扫描 (CT) 扫描.
- 进行了血栓过敏的测试.
主要成果:
- 患者在开始服用西马格卢蒂德的六个月内发生了肝内门静脉血栓.
- 最初没有发现静脉血栓塞栓症或血栓友爱症的已知危险因素.
- 检测到一个Janus激酶2突变,可能会增加血栓形成的风险.
结论:
- 为了减肥,GLP1-RA的使用越来越多,因此需要提高对潜在的血栓形成风险的认识.
- 在开始GLP1-RA治疗之前,医生必须仔细评估血栓形成风险.
- 这一案例强调了考虑罕见但严重的副作用的重要性.
相关概念视频
Esophageal Varices-II: Clinical Features and Management
37
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
37
Anticoagulant Drugs: Low-Molecular-Weight Heparins
601
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
601
Veins of the Abdomen and Pelvis
445
The human body is a complex system of interconnected parts, and the circulatory system plays a crucial role in maintaining overall health. One key component of this system is the inferior vena cava, a large vein responsible for returning blood from the abdominopelvic viscera and abdominal walls to the heart.
The inferior vena cava is fed by numerous smaller veins. The lumbar veins, for instance, drain the posterior abdominal wall, emptying both directly into the inferior vena cava and into the...
The inferior vena cava is fed by numerous smaller veins. The lumbar veins, for instance, drain the posterior abdominal wall, emptying both directly into the inferior vena cava and into the...
445


