评估剂量-体积参数和血管内皮生长因子表达对前列腺癌患者直肠毒性的预测值
Marziyeh Mirzaeiyan1, Hossein Khanahmad2, Simin Hemati3
1Department of Medical Physics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Journal of medical physics
|February 10, 2025
概括
血管内皮生长因子 (VEGF) 和V65辐射剂量与前列腺癌患者的直肠直肠炎相关. 需要进一步的研究来证实VEGF的存在.
科学领域:
- 辐射瘤学 辐射瘤学
- 癌症治疗中的生物标志物
- 癌症治疗中的胃肠道毒性
背景情况:
- 放射治疗的反应因人而异,阻碍了个性化治疗.
- 目前的放射治疗侧重于剂量分配,而不是患者的生物学.
- 生物标志物对于量身定制放射治疗至关重要.
研究的目的:
- 评估剂量-体积参数和VEGF是否预测前列腺癌患者的直肠直肠炎.
- 探索VEGF水平与辐射诱导的直肠毒性之间的相关性.
- 评估V65作为直肠直肠炎的预测剂量参数.
主要方法:
- 研究了18名接受螺旋式断层疗法的前列腺癌患者.
- 在治疗前和治疗后测量血清血管内皮生长因子 (VEGF) 水平.
- 分析了剂量参数 (V65) 并将其与直肠直肠炎等级相关联.
主要成果:
- 在直肠毒性组 (P=0.008) 中,VEGF水平在治疗后显著增加.
- 在患有直肠毒性 (P=0.033) 的患者中,V65显著更高 (P=0.033).
- 在预处理过程中,VEGF和V65与毒性相关性最强 (-0.446和0.450).
结论:
- VEGF表达与辐射直肠炎的病理生物学有关.
- 辐射直肠炎的发病过程复杂,涉及多个因素.
- 需要更多的研究来验证VEGF用于早期检测直肠炎.
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