非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比率和血清甲状腺功能的测量之间的关联:NHANES 2007-2012和门德尔随机化的最新发现
Mo-Yao Tan1, Ping Zhang1, Shan Wu2
1Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, Sichuan, China.
Frontiers in endocrinology
|February 10, 2025
概括
非高密度与高密度脂蛋白胆固醇的比率 (NHHR) 与自由甲状腺素 (FT4) 和甲状腺激素的比率有负相关性. 这一发现表明,NHHR可能是甲状腺功能和代谢健康的临床指标.
科学领域:
- 内分泌学 在内分泌学.
- 流行病学 流行病学
- 脂质代谢 脂质代谢是什么
背景情况:
- 有限的流行病学数据存在于血脂和甲状腺激素之间的关系.
- 非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率 (NHHR) 是脂质特征的标志物,但其与甲状腺功能的关联尚未得到充分证实.
研究的目的:
- 在大量成年人群中调查NHHR和甲状腺激素之间的关联.
- 探索NHHR作为甲状腺功能和代谢健康的临床指标的潜力.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2007-2012) 中分析了3881名成年人的数据.
- 甲状腺激素的测量:总三甲状腺氨酸 (TT3),自由三甲状腺氨酸 (FT3),总甲状腺氨酸 (TT4),自由甲状腺氨酸 (FT4) 和甲状腺刺激激素 (TSH).
- 应用调查加权线性回归,受限立方线 (RCS) 模型,以及带有逆方差加权 (IVW) 的门德尔随机化 (MR) 模型.
主要成果:
- 在对共变量进行调整后,在NHHR和FT4,FT4/FT3比率和TT4/TT3比率之间发现了显著的负相关性.
- 观察和MR分析表明,常见的脂质参数 (HDL,LDL,总胆固醇) 可能不会显著影响甲状腺功能障碍或甲状腺功能障碍风险.
结论:
- NHHR显示了与FT4和特定甲状腺激素比率 (FT4/FT3,TT4/TT3) 的负相关性.
- NHHR可以作为评估甲状腺功能和整体代谢健康的有价值指标.
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