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以前有恶性病的捐赠者:什么时候可以安全地进行器官移植?

Vitor Turra¹, Joao Manzi¹, Sarah Rombach¹

¹Miami Transplant Institute, Jackson Memorial Hospital, University of Miami, Miami, FL, United States.

Transplant international : official journal of the European Society for Organ Transplantation

|February 10, 2025

概括

器官捐赠正在增加,但缺乏仍然存在. 利用有癌症病史的老年捐赠者可能会扩大捐赠者群,但需要对捐赠者传播癌症 (DTC) 进行仔细的风险评估.

科学领域:

移植免疫学移植免疫学
在瘤学瘤学.
公共卫生公共卫生

背景情况:

美国的器官捐赠从2012年到2022年增加了50%,但每天有17名患者在等待移植时死亡.
超过103,544个人在移植等待名单上 (2023年8月),其中85.7%需要脏.
老年捐赠者 (≥65岁) 越来越多地被考虑扩大捐赠者池,尽管潜在的恶性病史.

研究的目的:

审查使用有恶性病史的捐赠者的挑战和益处.
分析捐赠者传播癌症 (DTC) 的风险与器官移植的需要.
改进来自老年捐献者的安全器官移植策略.

主要方法:

关于捐赠者传播癌症 (DTC) 的当前知识的文献综述.
对利用有恶性瘤病史的捐赠者进行决策过程的分析.
检查癌症类型,阶段和患者生存结果.

主要成果:

在2022年,7%的器官捐赠者年龄在65岁及以上.
使用具有恶性瘤史的捐赠者会带来复杂性,包括DTC的风险.
在决策过程中,平衡DTC风险与移植的紧迫性至关重要.

结论:

仔细考虑癌症史,类型,阶段和患者的结果是必不可少的.
来自有恶性瘤病史的老年捐赠者的安全器官移植策略需要改进.
通过这一人口群体扩大捐赠者池需要平衡风险和收益.

关键词:

癌症癌症癌症癌症癌症捐赠者捐赠者捐赠者提供者恶性瘤是一种恶性瘤.危险的风险危险的风险移植手术移植手术移植手术

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