相关实验视频

Updated: May 28, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

使用热敏凝与聚合物固体微针相结合,增强和持续通过皮肤输送氧化

Siti Nur Fatimah S Mohamad¹, Stephanie Stephanie², Zulfiayu Sapiun³

¹Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar 90245, Indonesia.

|February 10, 2025

概括

这项研究开发了一种具有聚合物固体微针 (PSMN) 的新型热敏凝 (TRG),用于增强通过皮肤输送氧皮醇 (OXY),提供有前途的痛风治疗. 综合系统显著改善了OXY透率,这表明了更高效,更为患者友好的选择.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
生物医学工程生物医学工程

背景情况:

痛风是由单酸盐晶体沉积引起的.
氧普林醇 (OXY) 是普林醇的关键代谢物,但由于溶解性差以及患者对当前方法的不适,它面临着输送挑战.
目前存在的OXY输送途径受到溶解性和患者服药性的限制.

研究的目的:

开发和评估一种新型的药物输送系统,用于oxypurinol (OXY) 使用热敏凝 (TRG) 与聚合物固体微针 (PSMNs) 集成.
为了增强OXY的通过皮肤传递,用于潜在的慢性痛风治疗.
评估OXY装载TRG-PSMN系统的物理化学特性,安全性和有效性.

主要方法:

分子对接被用来评估OXY和Pluronic相互作用.
热敏凝 (TRG) 配方的特点是凝温度,pH值,可扩散性和生物粘合性.
聚合物固体微针 (PSMNs) 被制造并评估了机械强度和穿透皮肤.
进行了体外血解,药物释放和体外皮肤透的研究.

主要成果:

分子对接揭示了OXY和Pluronic之间的高亲和结合.
TRG配方表现出适合通过皮肤传递的特性,PSMN显示出有效的皮肤透 (高达504微米).
该系统显示出良好的安全性 (血液溶解<5%) 和持续的OXY释放,PSMN显著提高了79-81%的ex vivoOXY透率.

结论:

一种热敏凝 (TRG) 与聚合物固体微针 (PSMNs) 结合,成功地开发出一种可增强氧皮醇 (OXY) 透皮输送的热敏凝.
这种新型的输送系统表明了更有效,更易于使用的慢性痛风治疗的潜力.
进一步的体内研究是有必要的,以评估临床应用的全部治疗潜力和安全性.

更多相关视频

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

相关概念视频

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

Non-Oral Extravascular Drug Absorption Routes

Non-Oral Extravascular Drug Absorption Routes

Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Routes of Drug Administration: Parenteral

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...