在 sodium-Glucose Cotransporter-2 抑制剂启动后,揭露常态血性原发性甲状腺功能障碍症
Christodoulos Dolapsakis1, Emmanouil Karofylakis1, Stamatios Chalvatzis1
14 Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.
European journal of case reports in internal medicine
|February 10, 2025
概括
-葡萄糖共运输体-2 (SGLT2) 抑制剂可以揭露原发性副甲状腺功能障碍症,导致敏感患者的高血症. 在开始使用SGLT2抑制剂之前,建议在边界水平的患者进行基线副甲状腺激素 (PTH) 测试.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- -葡萄糖共运输体-2 (SGLT2) 抑制剂越来越多地用于糖尿病和心力衰竭.
- 已知SGLT2抑制剂对矿物代谢有影响,包括对副甲状腺激素 (PTH) 水平的潜在影响.
- SGLT2 抑制剂与骨代谢之间的相互作用是复杂的,并未完全理解.
研究的目的:
- 报告一种SGLT2抑制剂诱导的高血症病例.
- 调查SGLT2抑制剂诱导的高血症的机制,在初级甲状腺功能障碍症的背景下.
- 提出一种临床策略,用于识别有风险的患者.
主要方法:
- 案例报告的呈现方式.
- 关于SGLT2抑制剂和矿物代谢的相关文献的审查.
- 分析患者数据,包括,PTH和维生素D水平.
主要成果:
- 在启用SGLT2抑制剂后,确定了一例高血症病例.
- 这种高血症归因于先前患有常态血病的患者的未掩盖的原发性副甲状腺炎症.
- SGLT2 抑制剂可以在患有潜在的常态血性原发性甲状腺功能障碍症的患者中导致明显的甲状腺功能障碍症和甲状腺功能障碍症.
结论:
- SGLT2 抑制剂可以加剧或揭露原发性副甲状腺功能障碍症,导致高血症.
- 在开始使用SGLT2抑制剂之前,建议在患者的水平处于正常的上限之前进行基线副甲状腺激素 (PTH) 测量.
- 建议在服用维生素D补充剂的患者特别小心,因为这种补充剂有可能掩盖常态血性原发性甲状腺功能障碍症.
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