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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
211
Transcription Attenuation in Prokaryotes02:42

Transcription Attenuation in Prokaryotes

15.1K
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure.  Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Leaky Scanning02:28

Leaky Scanning

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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相关实验视频

Updated: May 28, 2025

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
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Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

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在Mycobacterium tuberculosis与宿主相互作用中的长非编码RNA转录.

Mahalakshmi Vijayaraghavan1, Shrikanth S Gadad1,2,3, Subramanian Dhandayuthapani4,2

  • 1Center of Emphasis in Cancer, Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center El Paso, Texas-79905, USA.

Non-coding RNA research
|February 10, 2025
PubMed
概括

长非编码RNAs (lncRNAs) 是结核病发病的关键调节者. 了解IncRNA在Mycobacterium结核病感染中的作用,为宿主-病原体相互作用和潜在的治疗点提供了新的见解.

关键词:
主机-mtb互动的交互免疫反应的免疫反应.巨细胞是一个巨细胞.结核病菌菌菌的结核病菌的结核病菌.生存策略的生存策略.在 lncRNAs 中.

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A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
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Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
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Published on: February 28, 2025

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A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
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科学领域:

  • 分子生物学分子生物学
  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学

背景情况:

  • 结核病 (TB) 仍然是一个全球卫生挑战,持续的发病率和死亡率.
  • 结核菌菌 (Mycobacterium tuberculosis,Mtb) 是一种细胞内病原体,可以逃避宿主的免疫防御.
  • 迫切需要新的结核病诊断和治疗方法,需要对Mtb病变的更深入的理解.

研究的目的:

  • 审查最近关于长非编码RNAs (lncRNAs) 在结核病发病过程中的作用的文献.
  • 探索 lncRNAs 如何影响 Mtb 主体相互作用.
  • 突出 lncRNAs 在开发新型结核病控制策略中的潜力.

主要方法:

  • 对结核病中 lncRNAs 的研究进行文献综述.
  • 分析Mtb感染细胞和结核病患者组织中的IncRNA调节.
  • 检查 lncRNA 功能的调节宿主免疫反应,如亡和自.

主要成果:

  • 在结核病中,lncRNAs的调节方式不同.
  • 失调的lncRNAs在宿主免疫反应,亡和自中发挥着关键作用.
  • lncRNAs通过调节宿主细胞功能来影响Mtb病变.

结论:

  • lncRNAs正在成为结核病发病的关键参与者.
  • 研究lncRNAs为Mtb主机相互作用提供了宝贵的见解.
  • lncRNAs代表了新型结核病诊断和治疗的潜在目标.