对酒精相关腺症患者肝脏和胰腺功能的评估 - 一项病例对照研究
E Elavarasi1, Vinothini Gunasekaran1, Mohan Thirumal1
1Department of Dentistry, Aarupadai Veedu Medical College and Hospital, Vinayaka Missions Research Foundation, (Deemed to be University), Kirumampakkam, Puducherry, India.
Journal of pharmacy & bioallied sciences
|February 10, 2025
概括
酒精性 sialadenosis,以腺扩大为特征,与升高的肝酶和胰腺标志物有关. 进一步的研究可能会确定sialadenosis作为与酒精有关的肝脏和胰腺疾病的诊断指标.
科学领域:
- 生物化学 生化学
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 腺症 (sialosis) 呈现为无症状的,对称的腺扩大.
- 它影响30-69岁的个体,并与慢性饮酒,内分泌系统疾病和肥胖症有关.
- 这种情况与炎症性或瘤性腺疾病不同.
研究的目的:
- 为了研究酒精性腺症患者和没有这种疾病的酒精个体之间的生化差异.
- 探索腺症作为酒精诱导的肝脏和胰腺功能障碍的标记物的潜力.
主要方法:
- 一项病例对照研究,涉及15名酒精性腺症患者 (A组) 和15名酒精对照患者 (B组).
- 测量了AST,ALT,GGT,ALP,粉酶和脂酶的血清水平,以评估肝脏和胰腺功能.
- 这项研究是在2013年9月至2014年7月期间在拉贾·穆提亚牙科学院和医院进行的.
主要成果:
- 与B组相比,A组的平均水平显著更高的玛-胺转移酶 (GGT),酸氨转移酶 (AST) 和氨转移酶 (ALT).
- 在A组观察到AST/ALT比率略有增加.
- 在患有酒精性 sialadenosis 的患者中观察到血清氨酶和脂酶水平升高.
结论:
- 生物化学发现表明,慢性酒精消费与腺症的发展之间存在相关性.
- 尽管有生物化学变化,但肝脏和胰腺功能在研究组中保持稳定.
- 腺需要进一步研究,作为潜在的肝脏和胰腺疾病的诊断生物标志物,与滥用酒精有关.
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