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Updated: May 28, 2025

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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Published on: January 13, 2017

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基质捕获在多基酸合成酶和酸酶域中:巨乳素形成的结构基础

Tyler M McCullough1,2, Vishakha Choudhary1,2, David L Akey1

  • 1Life Sciences Institute, Mary Sue Coleman Hall, 210 Washtenaw Ave., University of Michigan, Ann Arbor, MI 48109-2216, United States.

ACS catalysis
|February 10, 2025
PubMed
概括

研究人员使用1,3-二氨基酸 (DAP) 来捕获中间体,设计了类型二化酶 (TEs),揭示了这些酶如何形成巨乳抗生素. 这项工作有助于开发用于药物发现的新生物催化剂.

关键词:
麦克罗拉克托尼酶是一种巨大的酶.聚基化合成酶的作用基板的捕获方式提奥酸酶的使用方法不自然的氨基酸结合.在X射线晶体学.

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