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Updated: May 5, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

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Published on: August 21, 2016

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在以色列透析患者群体中,G1和G2变异的多民族流行率APOL1

Dror Ben-Ruby1,2, Danit Atias-Varon1,3, Maayan Kagan1,2,3

  • 1Genetic Kidney Disease Research Laboratory, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.

Clinical kidney journal
|February 10, 2025
PubMed
概括

在没有已知的撒哈拉以南非洲祖先的以色列人群中发现了Apolipoprotein L1 (APOL1) 风险变体G1和G2. 在衰竭病例中,G2变异显著增强,这表明它可能会增加这些群体的慢性病风险.

关键词:
在CKD中,它是最重要的.慢性功能衰竭 慢性功能衰竭民族身份 民族身份基因多形态的多态化葡萄细胞 (podocytes) 是一个细胞.

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The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
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