鱼油补充剂对代谢功能障碍相关的脂肪性肝病的有效性:一个元分析
Like Zhou1, Dongmei Sun1, Houqiao Bai1
1Department of Gastroenterology, Weihai Maternal and Child Health Hospital, Weihai, China.
Frontiers in nutrition
|February 10, 2025
概括
鱼油补充剂显著改善了三甘油,肝酶 (AST),胰岛素耐药性 (HOMA-IR) 和腰围在患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的患者. 这表明鱼油对MASLD管理有好处.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 鱼油具有抗炎性质,并积极影响脂质代谢.
研究的目的:
- 系统地评估鱼油补充剂在管理MASLD中的有效性.
- 评估鱼油对肝脏健康关键指标,代谢参数和MASLD患者人体测量的影响.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查和元分析.
- 在主要数据库 (Cochrane,Embase,PubMed,Web of Science) 进行了搜索,截至2024年9月.
- 使用Cochrane协作工具评估了偏见风险.
主要成果:
- 包括7个带有439名参与者的RCT.
- 在甘油三,酸氨酸转胺酶 (AST),HOMA-IR和腰围方面观察到显著的改善.
- 对于氨酸转胺酶 (ALT),氨基胺转酶 (GGT),BMI,HDL,LDL或总胆固醇没有发现显著的益处.
结论:
- 目前的证据支持鱼油补充作为对MASLD有益的干预措施.
- 鱼油可能在调节血脂和改善MASLD患者的葡萄糖代谢方面发挥作用.
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