低至中等收入国家的
Arjune Sen1,2, Charles R Newton2,3,4, Gift Ngwende2,5
1Oxford Epilepsy Research Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital.
Current opinion in neurology
|February 10, 2025
概括
低收入和中等收入国家的治疗可以通过新的移动应用程序,3D打印EEG设备和更新的世卫组织指南来改善. 这些创新解决了患者持续存在的诊断和治疗差距.
科学领域:
- 全球健康 全球健康
- 神经学 神经学
- 公共卫生政策 公共卫生政策
背景情况:
- 症在低收入和中等收入国家 (LMICs) 影响了不成比例的人数.
- 这些地区仍然存在严重的诊断和治疗差距.
- 文化,社会经济和基础设施因素有助于治疗差距.
研究的目的:
- 为了突出病护理的最新发展.
- 展示在资源有限的环境中改善病护理的实际机会.
- 解决LMICs中持续存在的诊断和治疗缺口.
主要方法:
- 综述了的诊断和治疗方面的最新进展.
- 分析全球卫生行动计划的实施策略.
- 探索社区参与模式,以减少耻辱.
主要成果:
- 世卫组织跨部门全球行动计划 (WHO IGAP) 和心理健康差距行动计划 (mhGAP) 的实施可以减少教育差距.
- 让社区领袖和传统治疗师参与,可以帮助减少与相关的耻辱感.
- 开发诸如诊断伴侣和3D打印式EEG耳机之类的工具,有望改善初级保健和偏远地区的诊断.
- 将 levetiracetam 列入世卫组织基本药物清单 (EML) 提供了更安全的抗发作药物 (ASM) 选择.
- 手术方案是一个潜在的治愈治疗选择,即使在LMICs.
结论:
- 移动应用程序,新型EEG原型,加强对ASM的访问,以及世卫组织iGAP的实施,为改善LMIC症护理提供了切实的机会.
- 促进双向学习也可以为高收入国家中服务不足的人群带来好处.
更多相关视频
10:22Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
Published on: December 6, 2016
20.1K
07:01Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
9.0K
相关概念视频
01:24Arteries of the Lower Limbs
177
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
177
01:13Seizures: Classification
299
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
299
01:08Antiepileptic Drugs: Sodium Channel Blockers
355
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
355
01:30Electroconvulsive Therapy
22
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
22
01:14Antiepileptic Drugs: Glutamate Antagonists
271
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
271
01:18Antiepileptic Drugs: GABAergic Pathway Potentiators
310
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
310