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基因疗法和基于RNA的治疗方法在瘤学中的体内载体化和输送系统

Julie Schock Vaiani¹, Mans Broekgaarden¹, Jean-Luc Coll¹

¹Univ. Grenoble-Alpes (UGA), INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, 38000 Grenoble, France. bbusser@chu-grenoble.fr.

|February 10, 2025

概括

基因和RNA疗法提供了针对癌症的新方法. 本综述涵盖了先进的输送系统,如纳米粒子和病毒载体,用于有效的体内癌症治疗.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
纳米医学是一种纳米医学.

背景情况:

基因和RNA基因疗法正在彻底改变瘤学.
针对性调节瘤基因和蛋白质对于癌症治疗至关重要.

研究的目的:

审查用于体内癌症治疗的有效载荷矢量化和输送系统的最新进展.
突出基因和RNA疗法的病毒和非病毒传递方法的创新.

主要方法:

讨论病毒和非病毒有机颗粒 (脂质纳米颗粒,聚合结构).
基于细胞的载体和工程外细胞囊泡的探索.
对瘤性病毒和病毒囊修饰进行审查,以加强向和免疫调节.

主要成果:

详细介绍了传递系统的物理化学特性和细胞内屏障策略.
介绍了针对性,免疫调节和克服生物障碍的创新.
考虑了当前的临床试验和监管方面.

结论:

先进的传递系统对于有效的体内基因和RNA癌症疗法至关重要.
组合疗法和个性化医疗方法是未来的方向.
安全和可扩展的生产对于临床翻译至关重要.

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