在瘤学中的口腔粘膜毒性
Alessandro Villa1,2, Michele Lodolo2, Stephen Sonis3,4
1Oral Medicine, Oral Oncology and Dentistry. Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.
Expert opinion on pharmacotherapy
|February 10, 2025
概括
免疫疗法和向药物等癌症治疗的口服毒性正在增加. 本综述涵盖了它们的原因,症状和管理,以改善患者的治疗结果和癌症治疗疗效.
科学领域:
- 在瘤学瘤学.
- 口腔医学是指口腔医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔粘膜毒性是癌症治疗的重要并发症,包括化疗,放射治疗,免疫治疗和向药物.
- 这些毒性可以表现为口腔粘膜炎,口腔炎,与免疫相关的不良事件和药物诱导的病变,导致发病率并危及癌症治疗.
- 新型癌症疗法越来越普遍,需要对这些不良事件有充分的了解.
研究的目的:
- 审查与癌症治疗相关的口腔粘膜毒性疾病的流行病学,临床表现,病理生物学和当前的管理策略.
- 为了突出在不断变化的癌症治疗景观的背景下管理这些毒性的挑战.
- 强调需要精准医学方法和干预措施的严格临床测试.
主要方法:
- 本综述综合了关于口腔粘膜毒性的现有文献中的信息.
- 它讨论了流行病学数据,临床表现,潜在的病理生物学和当前的治疗干预措施.
- 该审查还考虑了新型癌症治疗对这些毒性的发生率和管理的影响.
主要成果:
- 口腔粘膜毒性是多种多样的,在新型癌症治疗中越来越常见.
- 了解病理生物学正在导致新的治疗策略.
- 患者反应的变化凸显了个性化治疗方法的必要性.
结论:
- 有效管理口腔粘膜毒性对于保持癌症治疗完整性和改善患者生活质量至关重要.
- 进一步的研究和临床试验的标准化对于完善预防和治疗策略至关重要.
- 精准医学有望将治疗量身定制为个别患者的个人资料,优化癌症治疗和毒性管理.
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