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瘤相关的巨细胞:非小细胞肺癌瘤微环境中的关键参与者

Tongtong Lv^1,2, Rui Fan¹, Jiaqi Wu^1,2

¹Department of Hematology, The First Affiliated Hospital of Yangtze University, Jingzhou, China.

Cancer medicine

|February 10, 2025

概括

与瘤相关的巨细胞 (TAMs) 驱动肺癌的进展和耐药性. 向TAM为增强免疫疗法和开发新的NSCLC治疗提供了一个有前途的战略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

肺癌是癌症死亡的主要原因,通常是晚期诊断出来的,存在诸如瘤异质性和耐药性等挑战.
与瘤相关的巨细胞 (TAMs),具有M1 (促炎) 和M2 (抗炎) 现型,显著影响非小细胞肺癌 (NSCLC) 的发病和进展.
巨细胞所分泌的细胞因子以及像RNA/蛋白质这样的物质对巨细胞两极分化的影响影响影响瘤免疫力,治疗疗效和患者预后.

研究的目的:

审查TAMs在NSCLC进展,耐药性和免疫治疗中的作用.
探索针对TAM用于NSCLC治疗的策略,包括修改瘤微环境.
评估基于TAM的系统在向药物或基因传递方面的潜力.

主要方法:

使用关键词: "TAMs"",NSCLC"",耐药性"",治疗"的PubMed系统文献综述.
对研究的质量和相关性进行选,以综合现有研究.

主要成果:

TAMs通过血管新生和上皮-介质细胞过渡 (EMT) 促进NSCLC的入侵,生长和转移.
TAMs有助于药物耐药性,并建立免疫抑制性瘤微环境,阻碍抗瘤免疫反应.
向TAM对于克服免疫抑制和提高NSCLC治疗效率至关重要.

结论:

TAMs是NSCLC免疫治疗的关键标,促进瘤的进展和抵抗.
减少TAM招募和调节其两极分化的策略对于NSCLC治疗至关重要.
基于TAM的系统提供精确的治疗药物,可能减少副作用并提高治疗结果.

关键词:

在NSCLCLC中,我们可以看到.这就是TAMs.生物标志物生物标志物药物耐药性耐药性药物耐药性治疗治疗治疗治疗治疗治疗

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