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Updated: May 28, 2025

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对于与NIMA相关的Kinase 7的选择性和强大的分子降解剂

Lu Chen1, Lu Huang2,3, Wuqiang Wen1

  • 1Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.

Angewandte Chemie (International ed. in English)
|February 10, 2025
PubMed
概括

研究人员开发了一种新型的分子降解剂 (MGD),向与NIMA相关的激酶7 (NEK7). 这种强大而有选择性的化合物LC-04-045通过抑制关键细胞因子,显示出治疗炎症性疾病的前景.

关键词:
分子降解器 分子降解器在 NEK7 基因酶.在 NLRP3 炎症酶体中,NLRP3 炎症酶体具有炎症性.激活NLRP3的激活方式蛋白质降解 蛋白质降解

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