母亲OM-85的使用通过降低IL-33/ILC2轴的调节来缓解后代的过敏气道炎症
Wei Zou1,2,3, Donghai Ma1, Fengfei Sun1,2
1Department of Pulmonary and Critical Care Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
概括
孕妇在怀孕期间服用OM-85可以通过改变肠道微生物群和增加有益的短链脂肪酸 (SCFA) 来减少后代的过敏呼吸道炎症,从而影响早期的免疫细胞发育.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 2型先天性淋巴细胞 (ILC2s) 对于免疫调节和组织平衡至关重要,特别是在过敏性喘中.
- 母亲肠道微生物群对新生儿ILC2发育和随后的过敏呼吸道炎症的影响尚不清楚.
- 这项研究调查了母体肠道微生物群改变对后代ILC2发育和过敏反应的影响.
研究的目的:
- 确定母体肠道微生物群调制如何影响后代的ILC2发育和过敏呼吸道炎症.
- 阐明母亲干预影响新生儿免疫编程的机制.
- 探索短链脂肪酸 (SCFA) 在调解这些效应中的作用.
主要方法:
- 孕妇小鼠在怀孕和哺乳期间服用OM-85.
- 在对OVA敏感的成年后代中评估过敏呼吸道炎症.
- 在后代中分析了ILC2的发育,IL-33和IL-25的产生以及肠道微生物群的组成.
- 研究了SCFA水平及其对IL-33分泌的影响.
主要成果:
- 母亲OM-85的使用显著降低了后代的ILC2-驱动的过敏气道炎症.
- OM-85抑制了IL-33和IL-25的产生,抑制了ILC2的扩张和生命早期的反应能力.
- 在后代中观察到增加的SCFA和SCFA产生细菌,与下调的IL-33表达有关.
- 通过抑制气皮素D (GSDMD) 的形成,SCFA降低了IL-33的分泌.
结论:
- 母亲OM-85的使用可以保护成年后代免受过敏性气道炎症的影响.
- 这种保护是由后代肠道SCFA增加的介导,这些SCFA在关键早期窗口期间调节ILC2发育.
- 这项研究突出了通过肠道微生物群对后代先天免疫力的母体免疫调节的跨代影响.
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