使用潜增长混合模型预测艾滋病毒老化成年人日常功能轨迹
Lillian Ham1,2, Scott Roesch3, Donald R Franklin4,5
1San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA. liham@health.ucsd.edu.
AIDS and behavior
|February 10, 2025
概括
大多数艾滋病毒感染老年人 (PWH) 保持稳定的日常功能. 然而,抑郁症和运动技能障碍预测下降,而慢性肺病可能有助于改善.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 艾滋病毒感染老年人 (PWH) 面临显著的不良健康结果,包括日常功能下降.
- 了解功能轨迹的模式和预测因素对于PWH至关重要.
- 艾滋病毒疾病特征和并发症可能会影响长期健康和日常生活.
研究的目的:
- 为了确定自我报告的日常功能在老龄化PWH.不同的轨迹.
- 检查这些功能轨迹的基线预测因素,包括人口统计,认知功能,并发症和艾滋病毒疾病特征.
主要方法:
- 潜增长混合模型被用来分析两年来742个PWH的数据.
- 参与者完成了多达五次半年访问,评估日常运作.
- 预测因素包括人口统计学,认知领域,精神病和医学并发症以及艾滋病毒疾病特征.
主要成果:
- 一个三类线性解决方案确定了不同的功能轨迹:稳定 (88%),恶化 (7%),改善 (5%).
- 抑郁症状和运动能力受损与功能障碍的可能性更高有关.
- 慢性肺病预测功能改善,而老年预测功能恶化.
结论:
- 大多数老年PWH都表现出稳定的日常功能.
- 针对抑郁症和运动技能障碍的有针对性的干预措施可以提高PWH的功能.
- 通过管理慢性肺病来潜在地表明的医疗保健参与可能与功能改善有关.
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