麻症对接受肝移植的患者生存的影响:元分析
Miho Akabane1, Yuki Imaoka1, Toshihiro Nakayama1
1Division of Abdominal Transplant, Department of Surgery, Stanford University Medical Center, Stanford, CA, 94305, USA.
Surgery today
|February 10, 2025
概括
肉症是一种肌肉损失的情况,在肝移植 (LT) 接受者中显著增加死亡风险. 在移植前评估肉症对于改善患者生存结果至关重要.
科学领域:
- 肝病学和移植外科手术
- 老年病学和老年学.
- 临床营养学 临床营养学
背景情况:
- 肉类症对肝移植后 (LT) 存活率的影响仍然不完全理解.
- 在接受LT的患者中,肉类是令人担忧的一个重要问题,影响了结果.
研究的目的:
- 进行一项全面的元分析,研究类病与肝移植接受者的死亡率之间的关联.
- 提供有关萨尔科佩尼亚对LT患者生存率的影响的最新证据.
主要方法:
- 在PubMed,Web of Science和EMBASE的系统文献搜索,截至2024年5月2日.
- 包括18个队列研究,包括6297名LT患者.
- 使用随机效应模型计算的聚合调整危险比率 (HRs).
主要成果:
- 总体上,肉类的患病率为27% (95% CI:26-28%),根据定义和患者特征而有所不同.
- 萨科佩尼亚与LT后死亡率的增加显著相关 (组合调整HR:1.55,95%CI1.28-1.89).
- 关联在各种子组和敏感性分析中持续存在,没有显著的异质性.
结论:
- 萨科佩尼亚是肝移植后死亡率增加的重要独立预测因子.
- 建议定期评估LT候选人的肉类风险,以优化移植前评估和患者管理.
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