在成长中的雌性大鼠中,在40%的热量限制期间,抵抗训练对骨的影响
Ken D Sumida1, Daniel L Smithers2, Aaron Gerston2
1Department of Health Sciences and Food Science Orange, Chapman University, One University Drive, Orange, CA, 92866, USA. sumida@chapman.edu.
Calcified tissue international
|February 10, 2025
概括
严重的卡路里限制可能会损害年轻女性的骨健康. 阻力训练 (RT) 帮助在限制饮食的老鼠中维持骨矿物质密度和机械特性,这表明RT可以防止骨质损失.
科学领域:
- 骨生理学和新陈代谢
- 运动科学和体育医学
- 营养科学与公共卫生
背景情况:
- 在正常体重的年轻女性中,严重的热量限制 (CR) 越来越普遍,对骨健康构成风险.
- 了解CR对骨发育的影响以及运动的潜在缓解作用至关重要.
研究的目的:
- 为了调查抵抗训练 (RT) 是否可以保持成长中的雌性大鼠的骨健康,这些雌性大鼠在六周内接受了严格的40%CR饮食.
- 评估RT在热量限制下对骨矿物质密度 (BMD) 和骨机械特性的影响.
主要方法:
- 一项为期六周的研究,涉及24只雌性大鼠,分为三个组:正常饮食 (N),久坐性40%CR饮食 (D) 和RT40%CR饮食 (DT).
- DT组每周三天使用重量进行梯子登.
- 使用双能X射线吸收计测量了腿骨 BMD,并评估了骨的机械特性.
主要成果:
- 与N组相比,卡路里限制在D组和DT组显著减少了体重.
- 与正常饮食组 (N) 相比,食用CR饮食 (D) 的静坐性大鼠的腿骨 BMD 显著下降7.9%.
- 与N相比,RT组 (DT) 的老鼠的小腿骨 BMD 仅有3.3%的不显著下降,它们的骨机械特性优于D组.
结论:
- 阻力训练表明,骨矿物质密度保持和改善成长中的雌性大鼠的骨机械性能,养严格的40%热量限制饮食.
- 这些发现表明,抵抗运动可能是一个可行的策略,以抵消严重的热量限制对年轻,成长中的个体骨健康的负面影响.
相关概念视频
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:40Bone Remodeling
38.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.1K
01:17Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
01:31Osteoclasts in Bone Remodeling
2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K