相关实验视频

Updated: May 28, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

长链非编码RNA-BANCR对甲状腺乳腺癌的进展及其机制的影响

Jiayi Yu¹, Kai Hong², Lingli Yao³

¹Medical School, Ningbo University, Ningbo, 315211, Zhejiang, China.

Discover oncology

|February 10, 2025

概括

激活BRAF的长非编码RNA (BANCR) 在乳头甲状腺癌 (PTC) 中起到瘤抑制作用. 减少BANCR表达与先进的PTC相关,抑制瘤生长和转移.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

乳头甲状腺癌 (PTC) 是最常见的甲状腺癌类型.
了解PTC进展背后的分子机制对于开发有效的治疗方法至关重要.
长非编码RNAs (lncRNAs) 正在成为各种癌症的关键调节者,包括PTC.

研究的目的:

研究BRAF激活的长非编码RNA (BANCR) 在乳头甲状腺癌 (PTC) 进展中的作用.
探索BANCR表达与PTC临床和分子特征的关联.
评估BANCR作为PTC中的预后标志物和治疗点的潜力.

主要方法:

从16名因淋巴结转移和哈希莫托甲状腺炎而分层的患者的PTC组织中分析BANCR表达.
功能性试验 (Transwell入侵,殖民地形成,CCK8) 评估BANCR在PTC细胞系中的生物效应.
生物信息学分析以确定与BANCR相关的途径,免疫细胞透和临床相关性.

主要成果:

与正常甲状腺组织相比,PTC组织中的BANCR表达显着较低.
减少的BANCR表达与瘤等级,淋巴结转移和T阶段相反相关.
过度表达BANCR抑制了PTC细胞的增殖,入侵和迁移,并与免疫细胞透和肌分数相关.

结论:

BANCR通过抑制瘤生长和转移而起到PTC中的瘤抑制作用.
BANCR有可能成为PTC的预后生物标志物.
针对BANCR可能为PTC提供一种新的治疗策略.

关键词:

这就是BANCR BANCR.哈西莫托的甲状腺炎长的非编码RNA是什么?乳头甲状腺癌是一种乳头甲状腺癌.

更多相关视频

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...