COVID-19 mRNA XBB.1.5的成本效益分析2023年秋季荷兰的疫苗接种
Florian Zeevat1,2, Simon van der Pol3,4, Tjalke Westra5
1Health-Ecore, Utrechtseweg 60, 3704 HE, Zeist, The Netherlands. florianzeevat@health-ecore.com.
Advances in therapy
|February 10, 2025
概括
对于荷兰的高风险人群来说,mRNA-1273 COVID-19 疫苗比 BNT162b2 具有显著的健康和经济益处. 如果价格具有竞争力,并确保国家免疫计划的成本效益,建议采用该方案.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 卫生经济学 卫生经济学
- 公共卫生政策 公共卫生政策
背景情况:
- 荷兰2023年COVID-19疫苗接种活动使用了更新的mRNA疫苗.
- 对XBB.1.5的mRNA-1273.222与BNT162b2的成本效益的比较尚未完全确定.
研究的目的:
- 评估mRNA-1273.222与BNT162b2相比的成本效益,用于2023年秋季的COVID-19疫苗接种活动.
- 为荷兰国家免疫计划提供有关高风险人群疫苗选择的信息.
主要方法:
- 采用了一个为期一年的决策树成本效益模型.
- 该模型评估了包括没有接种疫苗,BNT162b2和mRNA-1273接种疫苗的情景.
- 该分析从社会角度考虑了高风险人口 (≥60岁和风险较小的年轻人).
主要成果:
- 与BNT162b2.2.相比,mRNA-1273预计可以避免20629例症状病例,924例住院治疗,207例死亡和2124例COVID后病例.
- 据估计,该疫苗可以节省1290万欧元的社会成本,并获得1506个质量调整寿命年 (QALY).
- 对于mRNA-1273的平衡价格是16.72欧元或34.32欧元/获得的QALY,这取决于支付意愿的门.
结论:
- 在高风险人群中,mRNA-1273比BNT162b2具有优越的健康和经济效益.
- 如果 mRNA-1273 的价格不超过 34.32 欧元高于 BNT162b2.2,则支持采用 mRNA-1273.
- 这些发现支持将mRNA-1273纳入荷兰国家免疫计划.
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