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平等和母乳养是导致乳腺癌风险地理差异的因素
Boon Hong Ang1, Shivaani Mariapun1,2, Farahida Mohd Farid3
1Cancer Research Malaysia, 1, Jalan SS12/1A, 47500, Subang Jaya, Malaysia.
Cancer causes & control : CCC
|February 10, 2025
概括
城市化与亚洲女性的乳腺癌风险增加有关,原因是乳腺扫描密度增加. 平等和母乳养解释了城市和农村人口之间的一些差异.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 城市化是亚洲乳腺癌发病率上升的一个关键因素.
- 缺乏基于人口的潜在队列,特别是在低收入和中等收入国家,阻碍了对这种联系的理解.
- 乳腺扫描密度 (MD) 是与生活方式和生殖因素相关的强烈乳腺癌风险因素.
研究的目的:
- 调查导致城市和农村亚洲妇女乳腺癌风险差异的因素.
- 探索乳腺扫描密度 (MD) 在划分这些风险差异中的作用.
- 分析平等和母乳养对城市和农村人口的MD变异的影响.
主要方法:
- 在亚洲城市和农村地区的9417名妇女的横截面研究.
- 利用了医院或社区的机会性乳房学查数据.
- 采用回归和调解分析来确定与MD差异相关的因素.
主要成果:
- 城市地区的妇女与农村妇女相比,在年龄和BMI调整后的乳腺扫描密度 (MD) 显著更高.
- 调解分析表明,农村妇女的较高平价和母乳养部分解释了这些MD差异 (平价为7-9%,母乳养为2-3%).
- 平等对MD的影响因种族而异,在中国和马来妇女中是显著的,但不是印度妇女. 荷尔蒙使用,吸烟和身体活动并不能预测MD.
结论:
- 与农村妇女相比,城市亚洲妇女的乳腺扫描密度 (MD) 更高,部分原因是平等和母乳养做法.
- 城市化和MD差异所造成的风险的很大一部分仍然无法解释.
- 需要进一步的研究来确定影响乳腺癌风险差异的未知因素,以确定亚洲城市和农村人口之间的差异.
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