肠道疾病与牙周炎之间的关联:系统性审查和元分析
Yuebo Wu1,2,3, Daozhi Ji1,2,3, Xiaoqiu Chen1,2,3
1The Affiliated Stomatological Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
这项研究发现,牙周炎 (PD) 显著增加了炎症性肠病 (IBD) 和结直肠癌 (CRC) 的风险. 对患有这些全身性疾病的患者来说,管理牙疾病可能至关重要.
科学领域:
- 牙周病学 牙周病学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 越来越多的证据表明牙周炎 (PD) 与肠道疾病,如炎症性肠道疾病 (IBD) 和结直肠癌 (CRC) 之间存在联系.
- 需要进行全面的审查和元分析,以巩固有关这种关联的现有发现.
研究的目的:
- 系统地审查和分析有关牙周炎与炎症性肠病 (IBD) 和结直肠癌 (CRC) 之间的关联的现有文献.
- 量化IBD和CRC诊断的患者牙周炎的风险.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane Library,Web of Science) 进行了系统的搜索,搜索到2023年12月31日之前发表的研究.
- 统计分析涉及计算几率比率 (OR) 和95%置信区间 (CI),使用Review Manager版本5.4与固定效应模型.
主要成果:
- 患有IBD的患者显示PD的风险显著增加 (OR = 2.11).
- 在克罗恩病 (OR = 1.96) 和性结肠炎 (OR = 2.14) 患者中观察到PD风险升高.
- 发现了CRC和PD之间的直接关联,CRC患者患PD的风险增加了20% (OR = 1.20).
结论:
- 这一元分析强调了牙周炎与IBD和CRC等系统性疾病之间显著的关联.
- 牙周炎可能在患有炎症性肠道疾病和结直肠癌的患者的治疗中发挥关键作用.
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