纤维细胞生长因子5:家族高胆固醇血症的新生物标志物
Andrea Baragetti1,2, Asiiat S Alieva3, Liliana Grigore2
1Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzarett 9, 20133 Milan, Italy.
European heart journal
|February 10, 2025
概括
纤维细胞生长因子5 (FGF-5) 是一种有前途的生物标志物,用于识别家族性高胆固醇血症 (FH). 这种蛋白质可以区分FH患者和一般高胆固醇血症患者,即使LDL-C水平相似.
科学领域:
- 生物化学 生物化学
- 心血管医学 心血管医学
- 遗传学 是一个遗传学.
背景情况:
- 鉴定家族性高胆固醇血症 (FH) 是一个挑战,特别是没有遗传检测.
- 低密度脂蛋白胆固醇 (LDL-C) 单独不足以区分FH和一般高胆固醇血症 (HC).
- 需要新的生物标志物来准确诊断FH.
研究的目的:
- 调查心血管疾病和炎症生物标志物是否可以识别FH个体.
- 用血蛋白分析将FH患者与高胆固醇血 (HC) 患者区分开来.
主要方法:
- 分析了264个血蛋白质的小组.
- 机器学习算法被用来识别区分蛋白质.
- 纤维细胞生长因子5 (FGF-5) 在基因证明 (genFH) 和临床诊断 (clinFH) 个体,HC个体和对照中进行测量.
主要成果:
- 与对照组和HC个体相比,genFH和clinFH组的血FGF-5水平显著升高.
- 对于FGF-5的诊断准确度非常高 (曲线下的平均面积>0.990),可以区分FH与HC和对照组.
- 增加的FGF-5水平在所有分析的队列中都是一致的,即使在调整了LDL-C水平之后.
结论:
- 纤维细胞生长因子5 (FGF-5) 成为区分FH和HC个体的潜在生物标志物.
- FGF-5为改善FH识别提供了一个有前途的工具,特别是当基因测试不可用时.
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