阻塞性睡眠呼吸暂停和慢性病之间的关联:一个横截面和门德尔随机化研究
Shaokang Wang1,2, Yupei Cheng1,2, Zhe Zhang3
1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Medicine
|February 10, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与慢性病 (CKD) 有关,高血压和肥胖症作为关键调解者. 门德尔的随机化进一步支持OSA.
科学领域:
- 腎病學和睡眠醫學.
- 流行病学和遗传研究.
背景情况:
- 观察性研究表明,阻塞性睡眠呼吸暂停 (OSA) 和慢性病 (CKD) 之间存在相关性.
- 早期发现和治疗OSA可能对预防CKD进展至关重要.
研究的目的:
- 使用横截面方法调查OSA和CKD之间的关联.
- 探索肥胖和高血压在OSA-CKD关系中的调解作用.
- 使用孟德尔随机化 (MR) 评估OSA和功能障碍之间的因果关系.
主要方法:
- 利用了国家健康和营养检查调查 (2007-2008年和2015-2016年) 的数据.
- 使用后勤回归用于横截面分析和调解分析.
- 进行了单变量和多变量门德尔随机化 (MR) 分析.
主要成果:
- 横截面分析显示,OSA与患CKD的风险更高有关 (OR=1.14).
- 调解分析显示高血压 (41.83%) 和肥胖 (30.74%) 显著调解了OSA对CKD的影响.
- 核磁共振分析表明,基因预测OSA与功能障碍标志物 (例如,降低eGFRcystatin c,增加BUN,肌素,cystatin C) 有关,肥胖症调解这些影响.
结论:
- 在OSA和CKD之间存在显著的关联,由高血压和肥胖介导.
- 肥胖在OSA和功能障碍之间的因果关系中起着调解作用.
- 研究结果强调了管理OSA,高血压和肥胖对于预防CKD的重要性.
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