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从急性胰腺炎到糖尿病:儿童人口研究中的风险因素和时间分析
Michelle Saad, Lindsey Hornung1, Maisam Abu-El-Haija
1Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Pancreas
|February 10, 2025
概括
在急性胰腺炎 (AP) 后患上糖尿病的儿童面临更长的住院时间和更多的并发症. 早期查和随访对于管理胰腺炎后糖尿病 (PPDM) 风险至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 胃肠病学 胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 急性胰腺炎 (AP) 是儿童的一种严重疾病.
- AP的长期代谢后果,特别是糖尿病,还不太清楚.
- 鉴定胰腺炎后糖尿病 (PPDM) 的风险因素对于主动管理至关重要.
研究的目的:
- 为了确定一次AP事件后的儿科患者中PPDM的风险概况.
- 检查AP严重程度与相关并发症,停留时间 (LOS) 和重症监护室 (ICU) 要求之间的关系.
- 调查PPDM在AP后发展的发生率和时间.
主要方法:
- 使用儿科健康信息系统数据库 (2011-2020) 进行横截面研究.
- 包括年龄在19岁以下的患者和指数AP入院患者,不包括以前患有糖尿病 (DM) 或胰腺手术的患者.
- 在2012-2021年期间进行的糖尿病 (DM) 诊断查询.
主要成果:
- 在12822名儿科AP患者中,5.4%患有PPDM (320人在入院期间,366人后来).
- PPDM发病发生在AP后的中位数为1.9个月,范围广泛 (IQR:0-20.8个月).
- 在PPDM患者中,LOS较长,ICU需求增加,败血症,胰腺缩,囊形成,器官功能障碍和并发症.
结论:
- 儿童在急性胰腺炎期间或之后有患糖尿病的风险.
- 建议在出院后3-6个月内进行密切的门诊随访和加强糖尿病查.
- 早期发现和治疗PPDM可以减轻相关的并发症,并改善患者的治疗结果.
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