乳液凝稳定通过循环德克斯含/奇托桑复合物与不同程度的OSA替代度的生物活性化合物的联合封装
Sai Li1, Yacheng Hao2, Qunyu Gao1
1Carbohydrate Laboratory, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, PR China.
Food chemistry
|February 10, 2025
概括
这项研究开发了用于共同封装生物活性化合物的新型乳液凝. 经过优化,用酸酸盐无水化物修饰的环氧德素-复星/奇托 (OCD-R/CS) 凝增强了复星和β-胡卜素的稳定性和生物可访问性.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 生物活性化合物通常具有较差的溶解性和稳定性,限制了它们的应用.
- 乳液凝具有共同封装的潜力,但需要先进的配方策略.
- 研究了界面β-cyclodextrin (β-CD) 腔和内部油相,以提高输送效果.
研究的目的:
- 开发和表征八烯酸酸无水化物 (OSA) 修饰的环氧德素-白 (OCD-R) 纳入复合物.
- 形成OCD-R/奇托 (CS) 综合体,并评估它们在乳液凝中共同封装生物活性化合物的潜力.
- 评估配方对稳定性,生物可访问性和3D打印能力的影响.
主要方法:
- 准备具有不同程度替代 (DS) 的OCD-R纳入复合体.
- 通过静电相互作用形成OCD-R/CS复合体.
- 复合乳液凝的制造及其物理性质的表征 (ζ电位,界面张力,滴滴大小,质).
- 评估OCD1-R/CS乳液凝的β-胡卜素 (CAT) 稳定性和3D打印能力.
- 评估复星 (RES) 和CAT生物可访问性.
主要成果:
- 在循环德克斯林腔内成功封装复星得到证实.
- 增加OSA-修饰的环素的DS影响了 ζ电位和界面张力.
- 所有复合乳液凝都表现出不流动的,具有稳定的油滴大小的固体状特性.
- OCD1-R/CS乳液凝有效稳定了β-胡卜素,显示出出色的3D打印能力.
- 同封装显著改善了β-胡卜素的保留,并提高了白醇 (57.89%) 和β-胡卜素 (44.29%) 的生物可访问性.
结论:
- 经过乙烯氨酸无水化物修饰的环极-奇托桑复合物形成稳定的乳液凝,适用于共同封装生物活性化合物.
- 开发的乳液凝显示出改善可溶性较差的化合物如白醇和β-胡卜素的稳定性和生物可访问性的潜力.
- 这种方法为开发在食品和潜在的制药行业应用的先进交付系统提供了一个有前途的战略.
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